EndNote’s default location to save a library is in your “My Documents” folder for Windows users and in your Applications folder for Mac users. (You can see the location EndNote saves on your computer by going to your “Edit” menu, choosing “preferences,” and “folder locations.”)
You can save EndNote in a different location on your computer, but do not save your library to cloud storage (e.g. Dropbox, Sharepoint, Google Drive and iCloud, etc.). EndNote is not compatible with cloud storage, and your library may become corrupted. Also avoid sharing your library on a shared network as EndNote only alows one user to open a library, add, or edit records at one time.
When you create an EndNote library, you are creating two files. These two files must be kept together for your EndNote library to work properly. If you copy or move your library, keep these two files together.
One file is a .enl file. If you double-click on your .enl file, it will open your EndNote library.
The .Data folder stores additional information that your EndNote library needs to work properly. It also includes a subfolder where EndNote saves PDFs you've downloaded. (Do not rename or move these PDFs.)